Integrated infusion container

ABSTRACT

The present invention relates to unitary bottle for injection, more particularly, to a unitary medicine bottle having an integral structure where a medicine container is easily connected with a plastic container including a solution at a completely sterilized state so that powdered, freeze-dried or liquid medicine is mixed with the solution with one touch for a short time. The unitary medicine bottle for injection according to the present invention comprises: a plastic container equipped with a coupling member connected with a medicine container at one end and a releasing member for releasing a liquid medicine to be at the other end; a protection cap integrally formed with the coupling member to accept the medicine container; and a flue needle which moves forward in a direction of the medicine container and perforates a stopper of the medicine container and is inserted in the coupling member connecting the plastic container with the medicine container.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation of U.S. application Ser. No.13/400,852, filed Feb. 21, 2012, which is a continuation of U.S.application Ser. No. 11/994,186, filed Dec. 28, 2007 and now U.S. Pat.No. 8,128,612, which is a 371 of PCT/KR06/02522, filed Jun. 28, 2006,which in turn claims priority from Korean Patent Application No.10-2005-0056511, filed Jun. 28, 2005, the entire contents of each ofwhich are incorporated herein by reference.

TECHNICAL FIELD

The present invention relates to a unitary medicine bottle forinjection, more particularly, to a unitary medicine bottle having anintegral structure where a medicine container is easily connected with aplastic container including a solution at a completely sterilized stateso that powdered, freeze-dried or liquid medicine is mixed with thesolution with one touch for a short time.

BACKGROUND ART

In general, in order to administer powdered form or lyophilized(powder)form of anticancer medicine or a freeze-dried medicine to a patient in aclinic like a hospital, the powdered medicine included in a containerlike a vial is mixed with a certain amount of solution like a salinesolution and then it is instilled.

For instillation, methods for mixing the powered medicine with asolution are as follows. First, a solution like a saline solution isinjected into a vial with a throwaway syringe to dissolve the poweredmedicine, and the dissolved solution is transferred to the solutioncontainer with the throwaway syringe, also. This method is generallyused because it does not need additional equipment, but it isinadvantageous in that impurities may be infiltrated and operations arecomplicated.

Second, the container including the dissolved medicine is coupled withthe container including the solution using a coupling tool such as adouble-ended needle or a coupling tube. The container including thedissolved medicine is inclined so that the medicine dissolved in thecontainer is inserted into the container including the solution.

However, the above operations are complicated and time-consuming. Inparticular, as the operation for perforating a hole for connection on acontainer including a medicine is carried out in the air, thepossibility of contaminating the included medicine is increased.Moreover, the possibility of a nosocomial infection due to an abuse ofantibiotic injection is increased, also.

As a method for solving the above problem, a medicine bottle forinjection where a capsule receiving a vial being a medicine container isconnected with a plastic container filled with a solution having anoutlet of a liquid medicine by a tube has been developed.

In the tube, a hollow cavity needle is attached toward the vial and abreaking material like a tube made of plastic is attached toward theplastic container. The breaking material blocks a passage in the tubefor holding a liquid from flowing.

When using this, the vial in the capsule is pressed and a rubber stopperis pricked with the cavity needle to connect the plastic container withthe vial. The breaking material is broken with a finger for the passagein the tube to be reopened so that the medicine is mixed with thesolution.

The more improved one than the above medicine bottle for injectionincludes a plastic container having a liquid passage with an enclosureat the uppermost and filled with a solution or a diluted solution in themedicine bottle for injection, a capsule connected with the plasticcontainer, a medicine container connected by pricking its rubber stopperof which the inlet is closed with a needle and which is maintained inthe capsule and a flue means for connecting the inside of the plasticcontainer with the inside of the medicine container.

In addition, the flue means includes a hollow cavity needle having a hubin the middle and blades at both ends, a control means for perforating astopper of the medicine container by one blade of the cavity needle andan enclosure of the plastic container by the other blade of the cavityneedle in a serial order so as to connect the plastic container with themedicine container.

The above described medicine bottle for injection is improved in that amedicine container is connected with a plastic container including asolution, but a plurality of operations that the rubber stopper of avial is pricked by a cavity needle and a breaking material is brokenwith a finger to open the passage require quite a long time.

Moreover, when the breaking material is incompletely broken, there occurproblems that the solution is difficult to pass through the passage anda lot of time for dissolving it is required.

The above medicine bottle for injection is considered to be improved inthat a medicine is mixed by connecting a medicine container with aplastic container including a solution, and a shortened time consumedfor its operation. However, the medicine bottle for injection has aproblem that a flue means needs a hollow osteoplasty needle having a hubin the middle and blades at both ends and a complicatedly shaped controlmeans for controlling a connecting order so that one blade of theosteoplasty needle pricks the stopper of a medicine container first andthe other blade of it pricks the enclosure of the plastic container. Inaddition, as the medicine bottle for injection consists of a number ofparts, a manufacturing costs is high and the possibility of malfuntionsis increased.

In addition, there present various sizes of medicine containers. Theconventional medicine bottles for injection were manufactured inaccordance with the size of each medicine container. Therefore, it isinadvantageous in that the manufacturing cost is increased because amolding die must be manufactured for producing medicine bottle forinjections corresponding to the sizes of various medicine containers.

DISCLOSURE OF INVENTION Technical Problem

An object of the present invention to solve the above problems is toprovide a unitary medicine bottle for injection having an integralstructure where a medicine container is easily connected with a plasticcontainer including a solution at a completely sterilized state so thatpowdered, freeze-dried or liquid medicine is mixed with the solutionwith one touch for a short time.

Another object of the present invention is to provide a unitary medicinebottle for injection which can accept all sizes of medicine containers.

Technical Solution

In order to obtain the above objects, it is an object of the presentinvention is to provide a unitary medicine bottle for injectioncomprising: a plastic container having a coupling member to be connectedwith a medicine container at one end and a releasing member forreleasing a liquid medicine to be injected at the other end; aprotection cap integrally formed with the coupling member to accept themedicine container; and a flue needle which moves forward in a directionof the medicine container and perforates a stopper of the medicinecontainer and is inserted into the coupling member for connecting theplastic container with the medicine container.

The coupling member is characterized by comprising a guide section forguiding the flue needle and a diaphragm for supporting in contact withthe stopper of the medicine container.

In addition, the coupling member is characterized by comprising astopper for limiting forward movements of the flue needle.

Moreover, the protection cap is characterized by comprising a fixing capwhich is one body with the coupling member, a moving cap which isinterpolized or extrapolated in the fixing cap for changing its innerspace and a moving flange which is integrally formed with the fixingflange at an end of the fixing cap and fixed on the moving cap to set aspace for forming the moving cap and the fixing cap.

In addition, the protection cap is characterized by comprising a fixingpacking for holding the medicine container to be fixed.

Moreover, the protection cap is characterized by comprising a hangingmeans for hanging a medicine bottle.

In addition, the flue needle is characterized being a cavity needlehaving at least one connection passages through which a liquid medicineflows.

Moreover, the flue needle is characterized in that an interruptingprotuberance is formed at one side so that it stops at a predeterminedposition in the coupling member after it moved in order not to displacefurther.

The flue needle is characterized in that a fixing protuberance is formedat one side so that it is not easily displaced from the initial statewithout an external force.

In addition, the medicine container is formed of a glass or a plastic.

The stopper of the medicine container is formed of rubber or plastic.

In addition, the releasing member is characterized by comprising: anoutlet fixed to the plastic container so that a liquid medicine is notleaked; a releasing extended rim mounted at an inner end of the outlet;a releasing cap covering an end of the outlet to expose only the centerof the releasing extended rim; and a cover seal attached to the outsideof the releasing cap for sealing the releasing extended rim.

Moreover, the connection between a moving flange and a fixing flange,and the connection between the moving flange and the moving cap are madeby a thermal fusion, a supersonic fusion or a sealing bending.

Advantageous Effects

As described above, a unitary medicine bottle for injection according tothe present invention can be manufactured easily and in a low costbecause a medicine container and a plastic container do not move eachother, and the whole medicine container is compact and the number of theconsisting parts is small.

The medicine bottle has a structure where a sterilization process iseasily and perfectly carried out in manufacturing an injecting agent.Furthermore, as a medicine container and a plastic container can beconnected at a fixed state, it is possible to prevent a solution frombeing leaked or contaminated, in advance.

Moreover, the solution can be moved softly in a plastic container byusing a flue needle being a cavity needle. The medicine in the medicinecontainer and the solution can be mixed for a short time.

In addition, the protection cap accepting the medicine container isconstituted to comprise a fixing cap and a moving cap to accept allsizes of medicine containers in the medicine bottle of the presentinvention.

Therefore, it is possible to reduce the costs for manufacturing amedicine bottle corresponding to some medicine containers and a moldingdie.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a configurational view of a unitary medicine bottle forinjection in accordance with the present invention.

FIG. 2 is a cross-section of a stopper of a liquid medicine container.

FIG. 3 is a configurational view of a plastic container shown in FIG. 1.

FIG. 4 is a partial exploded view of a coupling member and a flue needleshown in FIG. 1.

FIG. 5 is a cross-section of a releasing extended rim.

FIG. 6 is an exploded view of a protection cap.

FIG. 7 is a cross-section of a packing.

FIG. 8 is a partial exploded view of an initial state of an embodiment.

FIG. 9 is a paritial exploded view of a displaced flue needle of anembodiment.

BEST MODE FOR CARRYING OUT THE INVENTION

In order to achieve the above objects, it is an object of the presentinvention is to provide a unitary medicine bottle for injectioncomprising: a plastic container having a coupling member to be connectedwith a medicine container at one end and a releasing member forreleasing a liquid medicine to be injected at the other end; aprotection cap integrally formed with the coupling member to accept themedicine container; and a flue needle which moves forward in a directionof the medicine container and perforates a stopper of the medicinecontainer and is inserted into the coupling member connecting theplastic container with the medicine container.

The coupling member is characterized by comprising a guide section forguiding the flue needle and a diaphargm for supporting in contact withthe stopper of the medicine bottle.

In addition, the coupling member is characterized by comprising astopper for limiting forward movements of the flue needle.

Moreover, the protection cap is characterized by comprising a fixing capwhich is one body with the coupling member, a moving cap which isinterpolized or extrapolated in the fixing cap for changing its innerspace and a moving flange which is integrally formed with the fixingflange at an end of the fixing cap and fixed on the moving cap to set aspace for forming the moving cap and the fixing cap.

In addition, the protection cap is characterized by comprising a fixingpacking for holding the medicine container to be fixed.

Moreover, the protection cap is characterized by comprising a hangingmeans for hanging a medicine bottle.

In addition, the flue needle is a cavity needle having at least onepassage through which a liquid medicine flows.

Moreover, the flue needle is characterized in that an interruptingprotuberance is formed at one side so that it stops at a predeterminedposition in the coupling member after it moved not to be displacedfurther.

The flue needle is characterized in that a fixing protuberance is formedat a side so that it is not easily displaced from the initial statewithout an external force.

In addition, the medicine container is formed of a glass or a plastic.

Moreover, the stopper of the medicine container is formed of rubber orplastic.

In addition, the releasing member is characterized by comprising: anoutlet fixed to the plastic container so that a liquid medicine is notleaked; a releasing extended rim mounted at an inner end of the outlet;a releasing cap covering the end of the outlet to expose only the centerof the releasing extended rim; and a cover seal attached to the outsideof the releasing cap for sealing the releasing extended rim.

Moreover, the connection between a moving flange and a fixing flange,and the connection between the moving flange and the moving cap are madeby a thermal fusion, a supersonic fusion or a sealing bending.

Mode for the Invention

FIG. 1 shows a unitary medicine bottle in accordance with the presentinvention, consisting of a plastic container (2), a protecting cap, areleasing member, a flue needle (11), the protecting cap being insertedby a medicine container (2).

The medicine container (2) is disclosed and is formed of plastic orglass.

The medicine container has a neck (7) at which a stopper (10) is formedto seal the contained medicine.

Moreover, the stopper (10) is hermetically sealed at the neck (7) of themedicine container (1) by an aluminum cover (not shown). Accordingly,the medicine filled in the medicine container (1) is protected at acompletely sterilized state.

The stopper (10) is inserted in the packing (8) to be conjugated betweenthe medicine container (1) and the coupling member (4) in an asepticcondition.

The stopper (10) is formed of rubber or plastic to have the same shapeshown in FIG. 2. The medicine included in the medicine container is usedby pricking the stopper (10) with an injection needle or a flue needleof a medicine bottle, etc.

The medicine in the medicine container is in a liquid or powdered state.The powdered medicine is dissolved to be used.

The medicine inserted into the medicine container includes cephem seriespre-antibiotics like Cefazolin Sodium, ceftizoxime sodium, Cefotiam HCLetc., penicillin series antibiotics like Ampicillin Sodium andpenicillin soldium etc., carbapenum series antibiotics like imipenem,various antibiotics like mitomycine C and fluorourcil, antiulcer agentslike Famotidine and hydrochloric acid Ranitidine, a thrombosis solventlike urokinase and flomoxef sodium.

The plastic container (2) is a synthetic resin pack used to contain asolution (3) like saline solution and may be formed of a material withaffluent plasticity such as a low density polyethylene resin, a linearlow density polyethylene resin, polypropylene resin, soft polyethyleneresin, chlorinated polyethylene resin, chlorinated vinyl resin andethylene acetic acid vinyl copolymer.

It is preferable to use a polyolefin series resin like a low densitypolyethylene resin, a linear low density polyethylene resin andpolypropylene resin because they are chemical resistant, has smalleffluents and cost-effective.

The solutions to be contained in the plastic container (2) includesolution including various electrolytes besides a saline solution, 5%dextrose solution and distilled water for injection.

As shown in FIG. 3, the plastic container (2) is equipped with acoupling member (4) connected with the medicine container (1) at one endand a releasing member (12) for releasing the liquid medicine to beinjected at the other end.

The coupling member (4) and the releasing member (12) are attached tothe plastic container (2) by a thermal fusion so that the solution isnot leaked.

As shown in FIG. 4, the coupling member (4) comprises a guide section(14) for guiding the flue needle (11) and a diaphragm (9) for supportinga stopper (10) of the medicine container (1).

In addition, a flange (22) formed at the side of the coupling member (4)is used together with the seats of the flue needle (11) with the samemethod as injecting a liquid medicine. In other words, the flue needle(11) is pushed upward by pressing the seats with a thumb and placing anindex finger and a middle finger on the flange (22).

A pipe is formed inside the coupling member (4) so that the flue needle(11) can make linear movements and an annular conjugation protuberance(25) is formed at an outer end so that the packing (8) is integrallysealed with the coupling member (4).

The diaphragm (9) of the coupling member (4) is formed in a dome to beclosely adhered to a central portion of the stopper (10) of the medicinecontainer (1).

Moreover, the diaphragm (9) has a thin layer which is easily perforatedby the flue needle (11). If it is blocked, it plays a role in sealingthe plastic container (2).

In addition, a stopper (15) is formed at the bottom of the couplingmember (4) to play a role in limiting a vertical movement distance ofthe flue needle (11).

The flue needle (11) inserted in the coupling member (4) is a cavityneedle with at least one passageway through which a liquid medicineflows, having the similar shape to a general injection syringe. The flueneedle (11) has a seat which is pressed by a finger at one end. The flueneedle (11) has a fixing protuberance (24) so that the flue needle (11)is not easily displaced from the initial state and an interruptingprotuberance (23) at one side so that the flue needle (11) is stopped ata predetermined position inside the coupling member (4) and not to bedisplaced further.

Accordingly, if the flue needle (11) is not applied by an external forcefrom the fixing protuberance (24) at the initial state, it is notdisplaced. If the flue needle (11) is applied by an external force, itis moved toward the diaphragm (9) along with the guide section (14) anddisaplced by a predetermined distance and is stopped by the interruptingprotuberance (23) and/or the stopper (15).

Therefore, the flue needle (11) moves forward and pricks the stopper(10) of the medicine container (1) and plays a role in connecting theinside of the medicine container (1) with the inside of the plasticcontainer (2), maintaining the state that the stopper is perforated.

The releasing member (12) consists of an outlet (21) which is closelyattached with the plastic container (2) so that a liquid medicine is notleaked, a releasing extended rim (16) which is mounted inside an end ofthe outlet (21), a releasing cap (20) for exposing only the center ofthe releasing extended rim (16) by covering one end of the outlet (20)and a cover seal (19) attached to the outside of the releasing cap (20)to seal the releasing extended rim (16).

The outlet (21) is thermally fused with the plastic container (2) to besealed. The releasing extended rim (16) made of a rubber, etc. (shown inFIG. 6) is forced to place inside of the outlet (21).

The cover seal (19) is attached to the outside of the releasing cap (20)by a thermal fusion or a supersonic fusion. Therefore, the medicinebottle for injection according to the present invention can be sealed atan asceptic state by attaching the cover seal (19). The protection capis integrally formed with the coupling member (4) to include a medicinecontainer (1).

Especially, as shown in FIG. 6, the protection cap includes a fixing cap(5) integrally formed with the coupling member (4), a moving cap (6)which is interpolated or extrapolated in the fixing cap (5) to changethe interal space, and a moving flange (18) which is integrallyconnected with the fixing flange (17) formed at one end of the fixingcap (5) and fixed to the moving cap (6) to set a space formed by themoving cap (6) and the fixing cap (5).

The connection with the moving flange (18) and the fixing flange (17)and the connection with the moving flange (18) and the moving cap (6)are carried out by a thermal fusion or a supersonic fusion.

The size of the internal space formed by the moving cap (6) and thefixing cap (5) is not limited, thus all sizes of medicine container (1)can use it.

The medicine container (1) mounted in the internal space formed by themoving cap (6) and the fixing cap (5) is protected from the externalimpact. The medicine container (1) is mounted with the stopper (10)inserted in the packing (8) mounted inside the fixing cap (5), upsidedown.

As shown in FIG. 7, the packing (8) is formed to wrap the stopper (10)and has a hole in the center so that the diaphragm (9) of the couplingmember (4) is inserted.

The fixing cap (5) and the moving cap (6) are formed of a polyolefinseries resin, a stylene series resin, an acryl series resin, apolycarbonate resin, polyamide resin, etc.

The fixing cap (5) and the moving cap (6) can sterilze their insideseasily by a λ-ray and a ultraviolet ray or a peroxide processing, usinga polypropylene resin which relatively penetrates an ultraviolet ray anda methylpentine resin.

A hanging means (13) has a hook or a hanging hole formed at the upperside of the moving cap (6), thus an unitary medicine bottle according tothe present invention is hung on a hanger to be stably kept.

The operating methods according to the present invention now will bedescribed.

First, the flue needle (11) is moved vertically from the outside of theplastic container (2) shown in FIG. 8 by pressing it toward thediaphragm (9) of the coupling member (4), as shown in FIG. 9.

The front end of the flue needle (11) is guided to the guide section(14) to penetrate the diaphragm (9) of the coupling member (4).

As the front end of the penetrated flue needle (11) penetrates thestopper (10) of the medicine container (1) and the flue needle (11) goesinside the medicine container (1), the inside of the medicine container(1) and the inside of the plastic container (2) are connected by a flueneedle being a cavity needle.

After the inside of medicine container (1) in connected with the insideof the plastic container (2), the plastic container (2) is pressurizedwith both hands slightly to send a part of solution into the medicinecontainer (1), thus dissolving the medicine.

In addition, a unitary medicine bottle for injection is shaken a fewtimes so that the medicine in the medicine container (1) is dissolvedfast.

Next, the liquid medicine dissolved in the medicine container (1) isreturned back to the plastic container (2) by the operations ofpressurizing or pressing the plastic container (2). The liquid medicineincluding the liquid medicine and the solution (3) which are mixed inthe plastic container (2) is released from the releasing means (12)attached at one end of the plastic container (2). At this time, thecover seal (19) is removed from the releasing cap (20) and a set ofmedicine bottle for injection is coupled to the releasing extended rim(16), thus a liquid medicine is instilled.

The foregoing embodiments are merely exemplary and are not to beconstrued as limiting the present invention. The description of thepresent invention is intended to be illustrative, and not to limit thescope of the claims. Many alternatives, modifications and variationswill be apparent to those skilled in the art within the scope of theinvention.

INDUSTRIAL APPLICABILITY

As described above, the unitary medicine bottle for injection accordingto the present invention does not move a medicine container and aplastic container each other. Therefore, as the medicine bottle iscompact and the number of constitutional parts is small, it is possibleto manufacture the unitary medicine bottle for injection easily andcost-effectively.

We claim:
 1. A unitary medicine bottle kit for injection comprising: acoupling member; a plastic container at a first end of the couplingmember; a medicine container at a second end of the coupling member; acap connected to the second end of the coupling member to accept themedicine container; a flue needle; a flange; a releasing member; and amedicine, wherein, the plastic container has a first end and a secondend, the coupling member is at the first end of the plastic container,the releasing member is at the second end of the plastic container, andthe first end of the plastic container is opposite the second end of theplastic container; the medicine container is penetrable; the capcomprises: a fixing cap which is one body with the coupling member; amoving cap interpolated within the fixing cap for altering the size ofan aseptic interior space when the moving cap moves; the flue needle isinserted into the coupling member, and the coupling member is fixed inreference to the plastic container and in reference to the fixing cap,wherein the flue needle moves towards the medicine container,penetrating the medicine container independently of the medicinecontainer; the medicine container is equipped with a stopper configuredto be penetrated by the flue needle; and the flange comprises: a fixingflange; and a moving flange; wherein the moving flange and the fixingflange are aligned with each other and conform to each other at an endof the fixing cap, and the moving flange is attached to the moving capand the fixing flange is fixed on the fixing cap to set the asepticinterior space; and the coupling member and the stopper are in directcontact when the stopper is pierced.
 2. The unitary medicine bottle kitof claim 1, wherein the medicine comprises a cephem seriespre-antibiotic.
 3. The unitary medicine bottle kit of claim 2, whereinthe cephem series pre-antibiotics is selected from the group consistingof cefazolin sodium, ceftizoxime sodium, and cefotiam hydrochloride. 4.The unitary medicine bottle kit of claim 1, wherein the medicinecomprises a penicillin series antibiotic.
 5. The unitary medicine bottlekit of claim 4, wherein the penicillin series pre-antibiotic is selectedfrom the group consisting of ampicillin sodium and penicillin sodium. 6.The unitary medicine bottle kit of claim 1, wherein the medicinecomprises a carbapenum series antibiotic.
 7. The unitary medicine bottlekit of claim 6, wherein the carbapenum series antibiotic is imipenem. 8.The unitary medicine bottle kit of claim 1, wherein the medicinecomprises an antibiotic.
 9. The unitary medicine bottle kit of claim 8,wherein the antibiotic is mitomycine C.
 10. The unitary medicine bottlekit of claim 8, wherein the antibiotic is fluorourcil.
 11. The unitarymedicine bottle kit of claim 1, wherein the medicine comprises anantiulcer agent.
 12. The unitary medicine bottle kit of claim 11,wherein the antiulcer agent is famotidine.
 13. The unitary medicinebottle kit of claim 11, wherein the antiulcer agent is hydrochloric acidranitidine.
 14. The unitary medicine bottle kit of claim 1 wherein themedicine comprises a thrombosis solvent.
 15. The unitary medicine bottlekit of claim 14, wherein the thrombosis solvent is urokinase.
 16. Theunitary medicine bottle kit of claim 14, wherein the thrombosis solventis flomoxef sodium.